WitrynaAims: Drug-induced QTc-prolongation, resulting from inhibition of HERG potassium channels may lead to serious ventricular arrhythmias and sudden death. We studied … WitrynaIntroduction: The aim of this study was to analyze the block of HERG-carried membrane currents caused by H 345/52, a new antiarrhythmic compound with low proarrhythmic activity, in transfected mouse fibroblasts. Methods and results: Using the whole-cell configuration of the voltage patch clamp technique, it was demonstrated that H …
Inhibition of the hERG potassium ion channel by different non ...
WitrynaInhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential ... (HCMV) polymerase activity, antiviral activity, and hERG inhibition. These results demonstrated that hERG ... WitrynaIn contrast, members of the HERG and K v LQT1 subfamilies assemble as homotetramers. The α- subunits that coassemble to form the various types of K + channels and their role in the generation of the action … dollar store east wenatchee
Ensemble of structure and ligand-based classification models for …
Witryna4 lut 2024 · Failure or inhibition of hERG channel activity caused by drug molecules can lead to prolonging QT interval, which will result in serious cardiotoxicity. Thus, … WitrynaThe human ether-á-go-go-Related gene product (hERG/K v 11.1) is notorious for broad-specific interaction with many promising candidate drugs that passed initial … WitrynaNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of … dollar store employee sprays febreze