WebApr 23, 2014 · This review focuses upon the development, scope, and utility of the highly versatile chemoselective alkoxyamine-based ‘neoglycosylation’ reaction first described … WebDec 6, 2013 · Here, we show that aniline derivatives such as 2-amino-5-methoxybenzoic acid enhance the rate of acid-catalyzed neoglycosylation for a range of sugar …
Synthesis of Neoglycopeptides via Click Chemistry
The traditional method for attaching sugars to natural products, drugs or drug leads is by chemical glycosylation. This classical approach typically requires multiple protection/deprotection steps in addition to the key anomeric activation/coupling reaction which, depending upon the glycosyl donor/acceptor pair, can lead to a mixture of anomers. Unlike classical chemical glycosylation, glycorandomization methods are divergent (i.e., diverge from a common starting material, see di… closest 67mm lens hood
Neoglycosylation and neoglycorandomization: Enabling tools for …
WebOct 22, 2015 · The neoglycosylation reacton, itself, is a chemoselective glycosylation between an N,O-dialkylhydroxyamine (a nucleophilic alkoxyamine) and an unprotected … WebApr 13, 2024 · Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a long-established, substantial role in the safety and pharmacokinetic … WebNeoglycosylation has been successfully employed for the activation of prodrugs (Thorson et al., 2001; Weymouth-Wilson, 1997) to modulate the specificity, toxicity and potency … closest aaa near me location