Radiomimetic drugs
Tīmeklis2024. gada 24. aug. · Alternatively, treatment with the radiomimetic DNA damaging chemotherapeutic drug Bleomycin (BLM) has frequently been used as a surrogate model of radiation-induced lung disease. The advantage of the BLM model is that the symptoms of pneumonitis and fibrosis develop within 1 month. TīmeklisSurvival is promoted through repair of these lesions by a number of DNA repair pathways. The efficacy of anticancer drugs is highly influenced by cellular DNA …
Radiomimetic drugs
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Tīmeklis2015. gada 12. okt. · The effect of the drug was estimated by immunoblotting and immunofluorescence microscopy using the antibody to phosphorylated histone H2AX (gH2AX), which is generally accepted as a DSB marker. At all stages of the cell cycle, both presenescent and young cells demonstrated variability of the number of gH2AX … The widening gap between the prevalence of multidrug resistant bacteria and the rate of development of antibiotics to target them with novel mechanisms of action has been identified as one of the three greatest health challenges by the World Health Organization and a microbial perfect storm by the … Skatīt vairāk Many pharmaceuticals traditionally relegated to cancer therapy have been re-examined in recent years for use in the treatment of other diseases. For example, vinca alkaloids have been utilized to treat successfully … Skatīt vairāk In this study, we have demonstrated that the radiomimetic glycopeptides such as Bleo and Tally demonstrate a general activity against Gram-negative bacteria, while radiomimetic … Skatīt vairāk
TīmeklisThe encouraging results obtained by Roswit and his associates (4) by combining roentgen irradiation with nitrogen mustard in the treatment of pulmonary carcinoma … Tīmeklisradiomimetic drug: An immunosuppressant–eg, an alkylating agent, used to treat CA that affects nucleic acids–eg, DNA, mimicking ionizing radiation
TīmeklisA radiomimetic drug is one that imitates the effects of radiation as in the case of chemicals such as nitrogen mustards which are used in cancer chemotherapy. The … http://www.ichacha.net/radiomimetic%20drug.html
Tīmeklis2007. gada 28. aug. · Bleomycin, a radiomimetic drug currently used in human cancer therapy, is a well known carcinogen. Its toxicity is mostly attributed to its potentiality …
TīmeklisDouble-strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as … dragon shield fenrirTīmeklisObjective: This study aims to examine the potential of radiomimetic compounds as antimicrobial therapeutics, as the recent advances in radiomimetic targeting as well … dragon shield eucalyptusTīmeklisINIS Repository Search provides online access to one of the world's largest collections on the peaceful uses of nuclear science and technology. The International Nuclear … dragon shield franceTīmeklisDefine radiomimetic. radiomimetic synonyms, radiomimetic pronunciation, radiomimetic translation, English dictionary definition of radiomimetic. adj. Having … dragonshield editionTīmeklis2014. gada 14. febr. · The radiation and radiomimetic drugs used to treat human tumors damage DNA in both cancer cells and normal proliferating cells. Centrosome … dragon shield ds3Tīmeklis2002. gada 14. jūn. · Bistranded clustered DNA damages involving oxidized bases, abasic sites, and strand breaks are produced by ionizing radiation and radiomimetic … dragon shield fury sleevesTīmeklisFor example, in mice, the radiomimetic drug neocarzinostatin changes the expression of over 70 miRNAs, and this response is ATM dependent [19]. The biogenesis of … dragon shield gaial