WebJul 15, 2013 · To determine whether the down-regulation of thoc1 plays an essential role in the CCL-34-induced macrophage-mediated cytotoxicity of cancer cells, several thoc1-overexpressing MBT-2 cell clones were established.A clone with a high expression level of thoc1 (designated as MBT-2/Thoc1#6) was chosen for subsequent experiments (Fig. 2 … WebSep 1, 2009 · It seems Thoc1 is required for prostate tumorigenesis initiated by Rb1 and p53 mutation. Preliminary data suggest that Thoc1 may also be important in human prostate cancer. Because cancer cells seem to be particularly sensitive to Thoc1 loss, Thoc1 and the TREX complex may provide novel targets for cancer therapy.
Functional significance of the Rb/Thoc1 interaction Cancer …
WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources Clinical data analysis was performed to explore the function of THOC1 in HCC. The representative images of immunohistochemistry downloaded from The Human Protein Atlas database indicated that the THOC1 expression was higher in tumors than that in normal liver tissues (Fig. 1a). Similarly, the clinical … See more THOC1 was knocked down or overexpressed in HCC cell lines to further verify its effect. Western blot analysis results indicated that THOC1 expression was … See more THOC1 can promote HCC cell proliferation in vitro. Hence, we further investigated the in vivo tumorigenic ability of THOC1. The tumors derived from PLC/PRF/5 cells … See more Based on the structure of THOC1, lead compounds with high docking scores to THOC1 were selected from the traditional Chinese medicine database by virtual … See more flaxbourne farm and gardens
The suppression of thoc1 in cancer cell apoptosis mediated by
WebThe THO complex 1 (Thoc1) is a nuclear matrix protein playing vital roles in transcription elongation and mRNA export. Recently, aberrant expression of Thoc1 has been reported in an increasing array of tumor types. However, the clinical significance of Thoc1 expression in colorectal cancer (CRC) is … WebMar 21, 2024 · Protein attributes for THOC1 Gene. Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least … WebMay 1, 2008 · The Thoc1 gene encodes a protein that binds the Rb N terminal domain. We hypothesize that some of Rb functions in vivo could be mediated in part by interaction with pThoc1. pThoc1 is an essential component of transcription export (TREX) complex and is required for early mouse embryonic development and the viability of transformed cells. cheer \u0026 co party supplies